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Crystal structure of the C domain of staphylococcal protein A in complex with the Fc fragment of human IgG at 2.3 Angstrom resolution

Source organisms:
Biochemical function: immunoglobulin binding
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
The deposited structure of PDB entry 4wwi contains 6 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin heavy constant gamma 3. Showing 2 copies in chain F.

PF02216
Domain description: B domain
Occurring in:
  1. Immunoglobulin G-binding protein A
The deposited structure of PDB entry 4wwi contains 3 copies of Pfam domain PF02216 (B domain) in Immunoglobulin G-binding protein A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
IPR009063
Domain description: Immunoglobulin/albumin-binding domain superfamily
Occurring in:
  1. Immunoglobulin G-binding protein A
IPR003132
Domain description: Protein A, Ig-binding domain
Occurring in:
  1. Immunoglobulin G-binding protein A

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Immunoglobulin heavy constant gamma 3
The deposited structure of PDB entry 4wwi contains 6 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin heavy constant gamma 3. Showing 2 copies in chain F.
1.20.5.420
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Immunoglobulin FC, subunit C
Occurring in:
  1. Immunoglobulin G-binding protein A
The deposited structure of PDB entry 4wwi contains 3 copies of CATH domain 1.20.5.420 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Immunoglobulin G-binding protein A. Showing 1 copy in chain A.

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