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The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin

X-ray diffraction
2.5Å resolution
PDB entry 4oso coloured by chain, front view.
PDB entry 4oso coloured by chain, side view.
PDB entry 4oso coloured by chain, top view.
Source organism: Streptomyces cyanogenus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Reductase homolog
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Multimeric state: homo tetramer
Accessible surface area: 32921.64 Å2
Buried surface area: 18724.67 Å2
Dissociation area: 3,493.31 Å2
Dissociation energy (ΔGdiss): 28.1 kcal/mol
Dissociation entropy (TΔSdiss): 14.86 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-195640

Macromolecules

Reductase homolog
Chains: A, B
Length: 263 amino acids
Theoretical weight: 27.5 KDa
Source organism: Streptomyces cyanogenus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ZGC1 (Residues: 2-253; Coverage: 100%)
Gene name: lanV
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
Reductase homolog in PDB entry 4oso, assembly 1, front view.
Reductase homolog in PDB entry 4oso, assembly 1, side view.
Reductase homolog in PDB entry 4oso, assembly 1, top view.
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