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Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3-sulfamoylbenzyl)ethanamide

X-ray diffraction
2.2Å resolution
PDB entry 4ng9 coloured by chain, front view.
PDB entry 4ng9 coloured by chain, side view.
PDB entry 4ng9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor VIIa complex
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Multimeric state: hetero dimer
Accessible surface area: 12946.55 Å2
Buried surface area: 3487.2 Å2
Dissociation area: 1,043.36 Å2
Dissociation energy (ΔGdiss): 7.07 kcal/mol
Dissociation entropy (TΔSdiss): 10.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140351
Complex Portal ID: CPX-6211

Macromolecules

Factor VII heavy chain
Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08709 (Residues: 213-466; Coverage: 57%)
Gene name: F7
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Factor VII heavy chain in PDB entry 4ng9, assembly 1, front view.
Factor VII heavy chain in PDB entry 4ng9, assembly 1, side view.
Factor VII heavy chain in PDB entry 4ng9, assembly 1, top view.
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Factor VII light chain
Chain: L
Length: 55 amino acids
Theoretical weight: 6.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08709 (Residues: 150-204; Coverage: 12%)
Gene name: F7
Pfam: Coagulation Factor Xa inhibitory site
CATH: Laminin
Factor VII light chain in PDB entry 4ng9, assembly 1, front view.
Factor VII light chain in PDB entry 4ng9, assembly 1, side view.
Factor VII light chain in PDB entry 4ng9, assembly 1, top view.
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