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Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol

Source organism: Homo sapiens
Biochemical function: NAD+ binding
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
The deposited structure of PDB entry 4hda contains 2 copies of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacylase sirtuin-5, mitochondrial. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR027546
Domain description: Sirtuin, class III
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
IPR026591
Domain description: Sirtuin, catalytic core small domain superfamily
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial

Structure domains

CATH CATH domains
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
The deposited structure of PDB entry 4hda contains 2 copies of CATH domain 3.40.50.1220 (Rossmann fold) in NAD-dependent protein deacylase sirtuin-5, mitochondrial. Showing 1 copy in chain B.
3.30.1600.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SIR2/SIRT2 'Small Domain'
Homology: SIR2/SIRT2 'Small Domain'
Occurring in:
  1. NAD-dependent protein deacylase sirtuin-5, mitochondrial
The deposited structure of PDB entry 4hda contains 2 copies of CATH domain 3.30.1600.10 (SIR2/SIRT2 'Small Domain') in NAD-dependent protein deacylase sirtuin-5, mitochondrial. Showing 1 copy in chain B.

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