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GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: protein maturation
Cellular component: perinuclear region of cytoplasm

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EC 2.4.1.41: Polypeptide N-acetylgalactosaminyltransferase

Reaction catalysed:
UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine
Systematic name:
UDP-N-acetyl-alpha-D-galactosamine:[protein]-3-O-N-acetyl-alpha-D-galactosaminyl transferase (configuration-retaining)
Alternative Name(s):
  • Glycoprotein acetylgalactosaminyltransferase
  • Polypeptide-N-acetylgalactosamine transferase
  • Protein-UDP acetylgalactosaminyltransferase
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
  • UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
  • UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase
  • UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase
  • UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase
  • UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase
  • UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase
  • UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
  • UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase
  • Uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00652
Domain description: Ricin-type beta-trefoil lectin domain
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
The deposited structure of PDB entry 4d0z contains 6 copies of Pfam domain PF00652 (Ricin-type beta-trefoil lectin domain) in Polypeptide N-acetylgalactosaminyltransferase 2. Showing 1 copy in chain A.

PF00535
Domain description: Glycosyl transferase family 2
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
The deposited structure of PDB entry 4d0z contains 6 copies of Pfam domain PF00535 (Glycosyl transferase family 2) in Polypeptide N-acetylgalactosaminyltransferase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000772
Domain description: Ricin B, lectin domain
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
IPR035992
Domain description: Ricin B-like lectins
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
IPR045885
Domain description: N-acetylgalactosaminyltransferase
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
IPR001173
Domain description: Glycosyltransferase 2-like
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2

Structure domains

CATH CATH domains
2.80.10.50
Class: Mainly Beta
Architecture: Trefoil
Topology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
The deposited structure of PDB entry 4d0z contains 6 copies of CATH domain 2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A)) in Polypeptide N-acetylgalactosaminyltransferase 2. Showing 1 copy in chain A.
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Polypeptide N-acetylgalactosaminyltransferase 2
The deposited structure of PDB entry 4d0z contains 6 copies of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Polypeptide N-acetylgalactosaminyltransferase 2. Showing 1 copy in chain A.

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