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Crystal structure of human BAZ2B bromodomain in complex with an acetylated histone 3 peptide (H3K14ac)

X-ray diffraction
1.99Å resolution
PDB entry 4qc1 coloured by chain, front view.
PDB entry 4qc1 coloured by chain, side view.
PDB entry 4qc1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Bromodomain adjacent to zinc finger domain protein 2B and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6547.02 Å2
Buried surface area: 1216.34 Å2
Dissociation area: 525.46 Å2
Dissociation energy (ΔGdiss): 14.4 kcal/mol
Dissociation entropy (TΔSdiss): 6.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165090
Assembly 2 (preferred)
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Assembly Name: Bromodomain adjacent to zinc finger domain protein 2B and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6762.4 Å2
Buried surface area: 1274.96 Å2
Dissociation area: 532.47 Å2
Dissociation energy (ΔGdiss): 13.59 kcal/mol
Dissociation entropy (TΔSdiss): 7.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165090

Macromolecules

Bromodomain adjacent to zinc finger domain protein 2B
Chains: A, B
Length: 107 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF8 (Residues: 2062-2166; Coverage: 5%)
Gene names: BAZ2B, KIAA1476
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromodomain adjacent to zinc finger domain protein 2B in PDB entry 4qc1, assembly 2, front view.
Bromodomain adjacent to zinc finger domain protein 2B in PDB entry 4qc1, assembly 2, side view.
Bromodomain adjacent to zinc finger domain protein 2B in PDB entry 4qc1, assembly 2, top view.
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acetylated histone 3 peptide (H3K14ac)
Chains: D, E
Length: 11 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
acetylated histone 3 peptide (H3K14ac) in PDB entry 4qc1, assembly 2, front view.
acetylated histone 3 peptide (H3K14ac) in PDB entry 4qc1, assembly 2, side view.
acetylated histone 3 peptide (H3K14ac) in PDB entry 4qc1, assembly 2, top view.
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