BAZ2A/BAZ2B, bromodomain (IPR037374)

Short name: BAZ2A/B_Bromo

Overlapping homologous superfamilies

Domain relationships

  • Bromodomain (IPR001487)
    • BAZ2A/BAZ2B, bromodomain (IPR037374)


Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain genes by cDNA library screening [PMID: 10662543]. They may play roles in transcriptional regulation. Human BAZ2A (also known as Tip5) is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus [PMID: 11532953]. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [PMID: 11911891].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.