Conserved Site

Bromodomain, conserved site (IPR018359)

Short name: Bromodomain_CS

Description

Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PMID: 1350857]. Bromodomains can interact with acetylated lysine [PMID: 9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PMID: 7580139].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns