PDBe 4dom

X-ray diffraction
1.8Å resolution

Crystal Structure of the TIR-domain of Human Myeloid Differentiation Primary Response protein (MyD88)


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q99836 (Residues: 157-296; Coverage: 47%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 33.415Å b: 57.991Å c: 62.495Å
α: 90° β: 90° γ: 90°
R R work R free
0.182 0.18 0.216
Expression system: Escherichia coli BL21(DE3)