Myeloid differentiation primary response protein MyD88 (IPR017281)

Short name: Myelin_different_resp_MyD88

Overlapping homologous superfamilies


Family relationships



Myeloid differentiation primary response protein MyD88 is an intracellular adaptor protein that has an essential role in innate immune signalling. It is vital for the proper responses of interleukin-1 and interleukin-18 and nearly all toll-like receptors (except TLR3) in the activation of transcription factors NF-kappa B and AP-1 followed by the induction of pro-inflammatory genes [PMID: 22996173].

MyD88 contains a TIR (Toll/Interleukin-1 receptor) domain and a death domain [PMID: 14993454]. The TIR domain is important for the protein's interaction with receptors, while the death domain is involved in signal transduction. For example, MyD88 interacts with IL-1R-associated kinase (IRAK)-4 through its death domain, and in turn, IRAK-4 activates other members of the IRAK family, like IRAK-1 [PMID: 11960013].

Defects in MYD88 are the cause of MYD88 deficiency [PMID: 18669862], also known as as recurrent pyogenic bacterial infections due to MYD88 deficiency.

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling

Molecular Function

GO:0070976 TIR domain binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.