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Structural and biochemical insights into MLL1 core complex assembly and regulation.

Source organism: Homo sapiens
Biochemical function: histone H3K4 methyltransferase activity
Biological process: regulation of tubulin deacetylation
Cellular component: ATAC complex

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EC 2.1.1.364: [Histone H3]-lysine(4) N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(4) N(6)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. WD repeat-containing protein 5
The deposited structure of PDB entry 3p4f contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in WD repeat-containing protein 5. Showing 7 copies in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. WD repeat-containing protein 5
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. WD repeat-containing protein 5
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. WD repeat-containing protein 5
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 5
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 5

Structure domain

CATH CATH domain
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. WD repeat-containing protein 5
The deposited structure of PDB entry 3p4f contains 1 copy of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in WD repeat-containing protein 5. Showing 1 copy in chain A.

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