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Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks

X-ray diffraction
2.054Å resolution
PDB entry 3moq coloured by chain, front view.
PDB entry 3moq coloured by chain, side view.
PDB entry 3moq coloured by chain, top view.
Source organisms:
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ig-like domain-containing protein, P3(40)
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Multimeric state: monomeric
Accessible surface area: 7016.18 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138351
Assembly 2
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Assembly Name: Ig-like domain-containing protein, P3(40)
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Multimeric state: monomeric
Accessible surface area: 7056.48 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138351
Assembly 3
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Assembly Name: Ig-like domain-containing protein, P3(40)
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Multimeric state: monomeric
Accessible surface area: 6945.1 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138351
Assembly 4
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Assembly Name: Ig-like domain-containing protein, P3(40)
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Multimeric state: monomeric
Accessible surface area: 7162.16 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138351
Assembly 5
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Assembly Name: Ig-like domain-containing protein, P3(40)
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Multimeric state: homo tetramer
Accessible surface area: 24682.19 Å2
Buried surface area: 3497.72 Å2
Dissociation area: 1,748.86 Å2
Dissociation energy (ΔGdiss): 5.04 kcal/mol
Dissociation entropy (TΔSdiss): 35.29 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138352

Macromolecules

Ig-like domain-containing protein; P3(40)
Chains: A, B, C, D
Length: 126 amino acids
Theoretical weight: 13.47 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q6X1E6 (Residues: 1-87, 102-113; Coverage: 88%)
  • Canonical: P05067 (Residues: 689-712; Coverage: 3%)
    • nullnull
Gene names: A4, AD1, APP
Pfam:
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 3moq, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 3moq, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 3moq, assembly 1, top view.
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