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Unreduced cathepsin L in complex with stefin A

X-ray diffraction
1.71Å resolution
PDB entry 3kse coloured by chain, front view.
PDB entry 3kse coloured by chain, side view.
PDB entry 3kse coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Procathepsin L and Cystatin-A
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Multimeric state: hetero dimer
Accessible surface area: 14042.35 Å2
Buried surface area: 1751.62 Å2
Dissociation area: 875.81 Å2
Dissociation energy (ΔGdiss): 4.66 kcal/mol
Dissociation entropy (TΔSdiss): 11.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133895
Assembly 2
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Assembly Name: Procathepsin L and Cystatin-A
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Multimeric state: hetero dimer
Accessible surface area: 14167.74 Å2
Buried surface area: 1771.78 Å2
Dissociation area: 885.89 Å2
Dissociation energy (ΔGdiss): 4.17 kcal/mol
Dissociation entropy (TΔSdiss): 11.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133895
Assembly 3
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Assembly Name: Procathepsin L and Cystatin-A
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Multimeric state: hetero dimer
Accessible surface area: 14135.17 Å2
Buried surface area: 1700.58 Å2
Dissociation area: 850.29 Å2
Dissociation energy (ΔGdiss): 4.21 kcal/mol
Dissociation entropy (TΔSdiss): 11.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133895

Macromolecules

Cathepsin L
Chains: A, B, C
Length: 220 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07711 (Residues: 114-333; Coverage: 70%)
Gene names: CTSL, CTSL1
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
Cathepsin L in PDB entry 3kse, assembly 1, front view.
Cathepsin L in PDB entry 3kse, assembly 1, side view.
Cathepsin L in PDB entry 3kse, assembly 1, top view.
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Cystatin-A
Chains: D, E, F
Length: 98 amino acids
Theoretical weight: 11.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01040 (Residues: 1-98; Coverage: 100%)
Gene names: CSTA, STF1, STFA
Pfam: Cystatin domain
InterPro:
CATH: Nuclear Transport Factor 2; Chain: A,
Cystatin-A in PDB entry 3kse, assembly 1, front view.
Cystatin-A in PDB entry 3kse, assembly 1, side view.
Cystatin-A in PDB entry 3kse, assembly 1, top view.
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