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BIOCHEMICAL CHARACTERIZATION AND STRUCTURE DETERMINATION OF HUMAN HEART SHORT CHAIN L-3-HYDROXYACYL COA DEHYDROGENASE PROVIDE INSIGHT INTO CATALYTIC MECHANISM

X-ray diffraction
2Å resolution
PDB entry 3had coloured by chain, front view.
PDB entry 3had coloured by chain, side view.
PDB entry 3had coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 25242.53 Å2
Buried surface area: 5363.16 Å2
Dissociation area: 1,605.38 Å2
Dissociation energy (ΔGdiss): 18.06 kcal/mol
Dissociation entropy (TΔSdiss): 13.65 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172593

Macromolecules

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Chains: A, B
Length: 308 amino acids
Theoretical weight: 33.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16836 (Residues: 13-314; Coverage: 96%)
Gene names: HAD, HAD1, HADH, HADHSC, SCHAD
Pfam:
InterPro:
CATH:
SCOP:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 3had, assembly 1, front view.
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 3had, assembly 1, side view.
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial in PDB entry 3had, assembly 1, top view.
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