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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.

X-ray diffraction
1.85Å resolution
PDB entry 2x4x coloured by chain, front view.
PDB entry 2x4x coloured by chain, side view.
PDB entry 2x4x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Peregrin and Histone H3.2
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Multimeric state: hetero dimer
Accessible surface area: 8402.27 Å2
Buried surface area: 1287.82 Å2
Dissociation area: 643.91 Å2
Dissociation energy (ΔGdiss): 6.59 kcal/mol
Dissociation entropy (TΔSdiss): 7.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157224
Assembly 2
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Assembly Name: Peregrin and Histone H3.2
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Multimeric state: hetero dimer
Accessible surface area: 8331.86 Å2
Buried surface area: 1346.51 Å2
Dissociation area: 673.26 Å2
Dissociation energy (ΔGdiss): 5.17 kcal/mol
Dissociation entropy (TΔSdiss): 7.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157224
Assembly 3
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Assembly Name: Peregrin and Histone H3.2
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Multimeric state: hetero dimer
Accessible surface area: 8247.53 Å2
Buried surface area: 1349.03 Å2
Dissociation area: 674.51 Å2
Dissociation energy (ΔGdiss): 5.08 kcal/mol
Dissociation entropy (TΔSdiss): 7.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157224
Assembly 4 (preferred)
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Assembly Name: Peregrin and Histone H3.2
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Multimeric state: hetero dimer
Accessible surface area: 8647.8 Å2
Buried surface area: 1580.05 Å2
Dissociation area: 713.19 Å2
Dissociation energy (ΔGdiss): 4.6 kcal/mol
Dissociation entropy (TΔSdiss): 8.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157224

Macromolecules

Peregrin
Chains: A, C, E, G
Length: 132 amino acids
Theoretical weight: 15.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55201 (Residues: 1076-1205; Coverage: 11%)
Gene names: BR140, BRPF1
Pfam: PWWP domain
InterPro: PWWP domain
CATH: SH3 type barrels.
Peregrin in PDB entry 2x4x, assembly 4, front view.
Peregrin in PDB entry 2x4x, assembly 4, side view.
Peregrin in PDB entry 2x4x, assembly 4, top view.
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Histone H3.2
Chains: B, D, F, H
Length: 21 amino acids
Theoretical weight: 2.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q71DI3 (Residues: 23-43; Coverage: 15%)
Gene names: H3C13, H3C14, H3C15, H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D
Histone H3.2 in PDB entry 2x4x, assembly 4, front view.
Histone H3.2 in PDB entry 2x4x, assembly 4, side view.
Histone H3.2 in PDB entry 2x4x, assembly 4, top view.
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