PWWP domain (IPR000313)

Short name: PWWP_dom

Overlapping homologous superfamilies


Domain relationships


The PWWP domain is an around 70 amino acids domain that was named after its central core 'Pro-Trp-Trp-Pro'. The PWWP domain is found in one or, less frequently, in two copies in nuclear, often DNA-binding proteins that function as transcription factors regulating developmental processes. Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, it has been proposed that the PWWP domain is involved in protein-protein interactions [PMID: 10802047].

Conservation of the PWWP domain is concentrated on one major and two minor blocks with length differences occurring in between [PMID: 10802047].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles