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The crystal structure of human SSADH in complex with SSA.

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: synaptic transmission, GABAergic
Cellular component: synapse

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EC 1.2.1.24: Succinate-semialdehyde dehydrogenase (NAD(+))

Reaction catalysed:
Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH
Systematic name:
Succinate-semialdehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • Succinate semialdehyde dehydrogenase (NAD(+))
  • Succinate semialdehyde:NAD(+) oxidoreductase
  • Succinic semialdehyde dehydrogenase (NAD(+))
  • Succinyl semialdehyde dehydrogenase (NAD(+))

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 2w8q contains 1 copy of Pfam domain PF00171 (Aldehyde dehydrogenase family) in Succinate-semialdehyde dehydrogenase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
IPR029510
Domain description: Aldehyde dehydrogenase, glutamic acid active site
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
IPR010102
Domain description: Succinate semialdehyde dehydrogenase
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 2w8q contains 1 copy of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in Succinate-semialdehyde dehydrogenase, mitochondrial. Showing 1 copy in chain A.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. Succinate-semialdehyde dehydrogenase, mitochondrial
The deposited structure of PDB entry 2w8q contains 1 copy of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in Succinate-semialdehyde dehydrogenase, mitochondrial. Showing 1 copy in chain A.

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