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Overview
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Pathways & interactions
Aldehyde dehydrogenase, C-terminal (IPR016163)
Short name: Ald_DH_C
Overlapping entries
- GPR domain (IPR000965)
- Delta l-pyrroline-5-carboxylate synthetase (IPR005766)
- Delta-1-pyrroline-5-carboxylate dehydrogenase (IPR005931)
- Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales (IPR005932)
- Delta-1-pyrroline-5-carboxylate dehydrogenase 3 (IPR005933)
- Methylmalonate-semialdehyde dehydrogenase (IPR010061)
- Succinate semialdehyde dehydrogenase (IPR010102)
- Betaine aldehyde dehydrogenase (IPR011264)
- 10-formyltetrahydrofolate dehydrogenase (IPR011407)
- Aldehyde dehydrogenase (IPR011408)
- Phenylacetic acid degradation protein PaaN (IPR011966)
- Phenylacetic acid degradation protein PaaN2 (IPR011975)
- 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (IPR011985)
- Bifunctional aldehyde-alcohol dehydrogenase (IPR012079)
- Glutamate-5-semialdehyde dehydrogenase (IPR012134)
- Aldehyde dehydrogenase NAD(P)-dependent (IPR012394)
- Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related (IPR012408)
- Acetaldehyde dehydrogenase, acetylating (IPR013357)
- Aldehyde dehydrogenase domain (IPR015590)
- Aminobutyraldehyde dehydrogenase (IPR015657)
- Aldehyde/histidinol dehydrogenase (IPR016161)
- 2-hydroxymuconic semialdehyde dehydrogenase (IPR017628)
- Succinylglutamate-semialdehyde dehydrogenase (IPR017649)
- Putative phosphonoacetaldehyde dehydrogenase (IPR017656)
- 1-pyrroline dehydrogenase (IPR017749)
- Methylmalonate-semialdehyde dehydrogenase, Gram-positive bacteria (IPR023510)
- Bifunctional protein PutA (IPR025703)
- Aldehyde dehydrogenase, Rv0768 family (IPR026460)
Description
This superfamily represents a structural domain found at the C-terminal of aldehyde dehydrogenases [PMID: 12795606]. These proteins contain two similar domains, each with a 3-layer alpha/beta/alpha structure, which probably arose from a duplication; this entry covers the C-terminal a/b/a domain. These enzymes bind NAD differently from other NAD(P)-dependent oxidoreductases.
Aldehyde dehydrogenases (EC:1.2.1.3 and EC:1.2.1.5) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known [PMID: 2713359]: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase.
GO terms
Biological Process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular Component
No terms assigned in this category.
Contributing signatures
- G3DSA:3.40.309.10 (G3DSA:3.40.309.10)