› › Function and Biology

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.7.11.25: Mitogen-activated protein kinase kinase kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKKKK-activated)
Alternative Name(s):
  • CMos
  • CRaf
  • MAP kinase kinase kinase
  • MAP3K
  • MAPKKK
  • MEK kinase
  • MEKK
  • MEKK1
  • MEKK2
  • MEKK3
  • MLK-like mitogen-activated protein triple kinase
  • MLTK
  • MLTKa
  • MLTKb
  • Mil/Raf
  • REKS
  • STK28

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF14604
Domain description: Variant SH3 domain
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10
The deposited structure of PDB entry 2rf0 contains 4 copies of Pfam domain PF14604 (Variant SH3 domain) in Mitogen-activated protein kinase kinase kinase 10. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10
IPR035779
Domain description: MLK1-3, SH3 domain
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10
IPR038383
Domain description: CGT/MARTX, cysteine protease (CPD) domain superfamily
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10

Structure domain

CATH CATH domain
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 10
The deposited structure of PDB entry 2rf0 contains 4 copies of CATH domain 2.30.30.40 (SH3 type barrels.) in Mitogen-activated protein kinase kinase kinase 10. Showing 1 copy in chain A.

Quick links