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Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

X-ray diffraction
2Å resolution
PDB entry 2rf0 coloured by chain, front view.
PDB entry 2rf0 coloured by chain, side view.
PDB entry 2rf0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase kinase kinase 10
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Multimeric state: monomeric
Accessible surface area: 3721.28 Å2
Buried surface area: 97.49 Å2
Dissociation area: 48.75 Å2
Dissociation energy (ΔGdiss): -0.33 kcal/mol
Dissociation entropy (TΔSdiss): -0.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169758
Assembly 2
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Assembly Name: Mitogen-activated protein kinase kinase kinase 10
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Multimeric state: monomeric
Accessible surface area: 3487.06 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169758
Assembly 3
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Assembly Name: Mitogen-activated protein kinase kinase kinase 10
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Multimeric state: monomeric
Accessible surface area: 3551.28 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169758
Assembly 4
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Assembly Name: Mitogen-activated protein kinase kinase kinase 10
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Multimeric state: monomeric
Accessible surface area: 3636.67 Å2
Buried surface area: 126.23 Å2
Dissociation area: 63.11 Å2
Dissociation energy (ΔGdiss): -0.6 kcal/mol
Dissociation entropy (TΔSdiss): -0.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169758

Macromolecules

Mitogen-activated protein kinase kinase kinase 10
Chains: A, B, C, D
Length: 89 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02779 (Residues: 13-78; Coverage: 7%)
Gene names: MAP3K10, MLK2, MST
Pfam: Variant SH3 domain
InterPro:
CATH: SH3 Domains
Mitogen-activated protein kinase kinase kinase 10 in PDB entry 2rf0, assembly 1, front view.
Mitogen-activated protein kinase kinase kinase 10 in PDB entry 2rf0, assembly 1, side view.
Mitogen-activated protein kinase kinase kinase 10 in PDB entry 2rf0, assembly 1, top view.
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