PDBe 2rf0

X-ray diffraction
2Å resolution

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Released:
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Eswaran J, Elkins J, Keates T, Pike ACW, Berridge G, Savitsky P, Sundstrom M, Arrowsmith CH, Weigelt J, Edwards AM, von Delft F, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 89 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02779 (Residues: 13-78; Coverage: 7%)
Gene names: MAP3K10, MLK2, MST
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3212
Unit cell:
a: 69.68Å b: 69.68Å c: 103.98Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.23
Expression system: Escherichia coli