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Crystal Structure of alpha1,3-Fucosyltransferase with GDP-fucose

Source organism: Helicobacter pylori
Biochemical function: fucosyltransferase activity
Biological process: protein glycosylation
Cellular component: membrane

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EC 2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

Reaction catalysed:
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-D-glucosaminyl-R
Systematic name:
GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Alternative Name(s):
  • GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase
  • GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase
  • GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
  • Galactoside 3-fucosyltransferase
  • Guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase
  • Lewis-negative alpha-3-fucosyltransferase
  • Plasma alpha-3-fucosyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00852
Domain description: Glycosyltransferase family 10 (fucosyltransferase) C-term
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
The deposited structure of PDB entry 2nzy contains 3 copies of Pfam domain PF00852 (Glycosyltransferase family 10 (fucosyltransferase) C-term) in Alpha-(1,3)-fucosyltransferase FucT. Showing 1 copy in chain C.

PF18025
Domain description: Alpha-(1,3)-fucosyltransferase FucT N-terminal domain
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
The deposited structure of PDB entry 2nzy contains 3 copies of Pfam domain PF18025 (Alpha-(1,3)-fucosyltransferase FucT N-terminal domain) in Alpha-(1,3)-fucosyltransferase FucT. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001503
Domain description: Glycosyl transferase family 10
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
IPR038577
Domain description: GT10-like, C-terminal domain superfamily
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
IPR041058
Domain description: Alpha-(1,3)-fucosyltransferase FucT, N-terminal
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
IPR016646
Domain description: Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, Helicobacter
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT

Structure domains

CATH CATH domains
3.40.50.11650
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycosyl transferase family 10, N-terminal domain
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
The deposited structure of PDB entry 2nzy contains 3 copies of CATH domain 3.40.50.11650 (Rossmann fold) in Alpha-(1,3)-fucosyltransferase FucT. Showing 1 copy in chain C.
3.40.50.11660
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycosyl transferase family 10, C-terminal domain
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
The deposited structure of PDB entry 2nzy contains 3 copies of CATH domain 3.40.50.11660 (Rossmann fold) in Alpha-(1,3)-fucosyltransferase FucT. Showing 1 copy in chain C.
SCOP SCOP annotation
159794
Class: Alpha and beta proteins (a/b)
Fold: UDP-Glycosyltransferase/glycogen phosphorylase
Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase
Occurring in:
  1. Alpha-(1,3)-fucosyltransferase FucT
The deposited structure of PDB entry 2nzy contains 3 copies of SCOP domain 159794 (FucT-like) in Alpha-(1,3)-fucosyltransferase FucT. Showing 1 copy in chain C.

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