Homologous Superfamily

GT10-like superfamily (IPR038577)

Short name: GT10-like_sf

Overlapping entries

Description

Glycosyltransferase family 10 (GT10) comprises enzymes with two known activities; galactoside 3(4)-L-fucosyltransferase (EC:2.4.1.65) and galactoside 3-fucosyltransferase (EC:2.4.1.152).

The galactoside 3-fucosyltransferases display similarities with the alpha-2 and alpha-6-fucosyltranferases [PMID: 9451017]. The biosynthesis of the carbohydrate antigen sialyl Lewis X (sLe(x)) is dependent on the activity of an galactoside 3-fucosyltransferase. This enzyme catalyses the transfer of fucose from GDP-beta-fucose to the 3-OH of N-acetylglucosamine present in lactosamine acceptors [PMID: 9042366].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins [Reid M.E., Lomas-Francis C. The Blood Group Antigen FactsBook Academic Press, London / San Diego, (1997)]. Galactoside 3(4)-L-fucosyltransferase (EC:2.4.1.65) belongs to the Lewis blood group system and is associated with Le(a/b) antigen.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D