› › Structure analysis

Crystal structure of IRAK-4

X-ray diffraction
2Å resolution
PDB entry 2nru coloured by chain, front view.
PDB entry 2nru coloured by chain, side view.
PDB entry 2nru coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14531.5 Å2
Buried surface area: 1025.48 Å2
Dissociation area: 450.41 Å2
Dissociation energy (ΔGdiss): -3.31 kcal/mol
Dissociation entropy (TΔSdiss): 5.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 2
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14545.39 Å2
Buried surface area: 1020.45 Å2
Dissociation area: 450.88 Å2
Dissociation energy (ΔGdiss): -2.5 kcal/mol
Dissociation entropy (TΔSdiss): 5.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 3
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14211.29 Å2
Buried surface area: 945.75 Å2
Dissociation area: 472.87 Å2
Dissociation energy (ΔGdiss): -1.72 kcal/mol
Dissociation entropy (TΔSdiss): 5.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669
Assembly 4
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14445.12 Å2
Buried surface area: 939.02 Å2
Dissociation area: 469.51 Å2
Dissociation energy (ΔGdiss): -1.69 kcal/mol
Dissociation entropy (TΔSdiss): 5.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669

Macromolecules

Interleukin-1 receptor-associated kinase 4
Chains: A, B, C, D
Length: 307 amino acids
Theoretical weight: 34.58 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 154-460; Coverage: 67%)
Gene name: IRAK4
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Interleukin-1 receptor-associated kinase 4 in PDB entry 2nru, assembly 1, front view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2nru, assembly 1, side view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 2nru, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links