Interleukin-1 receptor-associated kinase 4 (IPR017428)

Short name: IRAK4

Overlapping homologous superfamilies

Family relationships



This entry represents Interleukin-1 receptor-associated kinase 4 (IRAK4) (EC: IRAK4 is required for the efficient recruitment of IRAK1 to the interleukin-1 (IL-1) receptor complex following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilisation [PMID: 18524972, PMID: 17548806]. IRAK4 phosphorylates IRAK1. Pellino-2 may be a substrate for both IRAK1 and IRAK4 [PMID: 12860405].

Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [PMID: 16950813]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains.

Defects in IRAK4 are also the cause of IRAK4 deficiency [PMID: 15069404]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.

GO terms

Biological Process

GO:0006468 protein phosphorylation
GO:0007165 signal transduction

Molecular Function

GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.