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Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with Beta-trypsin at 1.55 Angstrons Resolution

Source organisms:
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: digestion
Cellular component: extracellular region

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EC 3.4.21.4: Trypsin

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Systematic name:
-
Alternative Name(s):
  • Alpha-trypsin
  • Beta-trypsin
  • Cocoonase
  • Parenzyme
  • Parenzymol
  • Pseudotrypsin
  • Sperm receptor hydrolase
  • Tripcellim
  • Tryptar
  • Tryptase
  • Trypure

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00228
Domain description: Bowman-Birk serine protease inhibitor family
Occurring in:
  1. Bowman-Birk serine protease inhibitors family domain-containing protein
The deposited structure of PDB entry 2g81 contains 2 copies of Pfam domain PF00228 (Bowman-Birk serine protease inhibitor family) in Bowman-Birk serine protease inhibitors family domain-containing protein. Showing 2 copies in chain B [auth I].

PF00089
Domain description: Trypsin
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2g81 contains 1 copy of Pfam domain PF00089 (Trypsin) in Serine protease 1. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR000877
Domain description: Proteinase inhibitor I12, Bowman-Birk
Occurring in:
  1. Bowman-Birk serine protease inhibitors family domain-containing protein
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Serine protease 1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Serine protease 1
IPR035995
Domain description: Bowman-Birk type proteinase inhibitor
Occurring in:
  1. Bowman-Birk serine protease inhibitors family domain-containing protein
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Serine protease 1
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Serine protease 1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Serine protease 1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Serine protease 1

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2g81 contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Serine protease 1. Showing 2 copies in chain A [auth E].
2.10.69.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cysteine Protease (Bromelain) Inhibitor, subunit H
Homology: Cysteine Protease (Bromelain) Inhibitor, subunit H
Occurring in:
  1. Bowman-Birk serine protease inhibitors family domain-containing protein
The deposited structure of PDB entry 2g81 contains 1 copy of CATH domain 2.10.69.10 (Cysteine Protease (Bromelain) Inhibitor, subunit H) in Bowman-Birk serine protease inhibitors family domain-containing protein. Showing 1 copy in chain B [auth I].
SCOP SCOP annotations
57248
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Bowman-Birk inhibitor, BBI
Occurring in:
  1. Bowman-Birk serine protease inhibitors family domain-containing protein
The deposited structure of PDB entry 2g81 contains 1 copy of SCOP domain 57248 (Bowman-Birk inhibitor, BBI) in Bowman-Birk serine protease inhibitors family domain-containing protein. Showing 1 copy in chain B [auth I].
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Serine protease 1
The deposited structure of PDB entry 2g81 contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Serine protease 1. Showing 1 copy in chain A [auth E].

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