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1.8 ANGSTROMS REFINED STRUCTURE OF THE LIPASE FROM GEOTRICHUM CANDIDUM

Source organism: Geotrichum candidum
Biochemical function: hydrolase activity
Biological process: lipid catabolic process
Cellular component: extracellular region

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EC 3.1.1.3: Triacylglycerol lipase

Reaction catalysed:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Systematic name:
Triacylglycerol acylhydrolase
Alternative Name(s):
  • Amano AP
  • Amano B
  • Amano CE
  • Amano CES
  • Amano P
  • Amno N-AP
  • Butyrinase
  • Cacordase
  • Capalase L
  • GA 56
  • GEH
  • Glycerol ester hydrolase
  • Glycerol-ester hydrolase
  • Heparin releasable hepatic lipase
  • Hepatic lipase
  • Hepatic monoacylglycerol acyltransferase
  • Lipase
  • Lipazin
  • Liver lipase
  • Meito MY 30
  • Meito Sangyo OF lipase
  • PPL
  • Post-heparin plasma protamine-resistant lipase
  • Salt-resistant post-heparin lipase
  • Steapsin
  • Takedo 1969-4-9
  • Triacetinase
  • Triacylglycerol ester hydrolase
  • Tributyrase
  • Tributyrin esterase
  • Tributyrinase
  • Triglyceridase
  • Triglyceride hydrolase
  • Triglyceride lipase
  • Triolein hydrolase
  • Tween hydrolase
  • Tween-hydrolyzing esterase
  • Tweenase
  • Tweenesterase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Lipase 2
The deposited structure of PDB entry 1thg contains 1 copy of Pfam domain PF00135 (Carboxylesterase family) in Lipase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Lipase 2
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Lipase 2
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Lipase 2
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Lipase 2

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Lipase 2
The deposited structure of PDB entry 1thg contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Lipase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
53558
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Lipase 2
The deposited structure of PDB entry 1thg contains 1 copy of SCOP domain 53558 (Fungal lipases) in Lipase 2. Showing 1 copy in chain A.

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