Carboxylesterase, type B (IPR002018)

Short name: CarbesteraseB

Overlapping homologous superfamilies

Domain relationships



Higher eukaryotes have many distinct esterases. Among the different types are those which act on carboxylic esters (EC:3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates [PMID: 3163407, PMID: 1862088, PMID: 8453375] that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.