Active Site

Carboxylesterase type B, active site (IPR019826)

Short name: Carboxylesterase_B_AS

Description

Higher eukaryotes have many distinct esterases. Among the different types are those which act on carboxylic esters (EC:3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates [PMID: 3163407, PMID: 1862088, PMID: 8453375] that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.

As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This entry represents a conserved sequence containing the active site serine.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns