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A 1.4 ANGSTROM CRYSTAL STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA CRUZI

X-ray diffraction
1.41Å resolution
PDB entry 1tc1 coloured by chain, front view.
PDB entry 1tc1 coloured by chain, side view.
PDB entry 1tc1 coloured by chain, top view.
Source organism: Trypanosoma cruzi
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxanthine phosphoribosyltransferase
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Multimeric state: homo dimer
Accessible surface area: 15383.55 Å2
Buried surface area: 4460.64 Å2
Dissociation area: 1,506.86 Å2
Dissociation energy (ΔGdiss): 17.33 kcal/mol
Dissociation entropy (TΔSdiss): 12.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-175481

Macromolecules

Hypoxanthine phosphoribosyltransferase
Chains: A, B
Length: 220 amino acids
Theoretical weight: 25.46 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4DRC4 (Residues: 22-241; Coverage: 91%)
Gene name: Tc00.1047053509693.70
Pfam: Phosphoribosyl transferase domain
InterPro:
CATH: Rossmann fold
SCOP: Phosphoribosyltransferases (PRTases)
Hypoxanthine phosphoribosyltransferase in PDB entry 1tc1, assembly 1, front view.
Hypoxanthine phosphoribosyltransferase in PDB entry 1tc1, assembly 1, side view.
Hypoxanthine phosphoribosyltransferase in PDB entry 1tc1, assembly 1, top view.
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