Hypoxanthine phosphoribosyl transferase (IPR005904)

Short name: Hxn_phspho_trans

Overlapping homologous superfamilies

Family relationships



Phosphoribosyltransferases (PRT) are enzymes that catalyze the synthesis of beta-n-5'-monophosphates from phosphoribosylpyrophosphate (PRPP) and an enzyme specific amine. A number of PRT's are involved in the biosynthesis of purine, pyrimidine, and pyridine nucleotides, or in the salvage of purines and pyrimidines. Purine nucleotides are synthesized both via the de novo pathway and via the salvage pathway and are vital for cell functions and cell proliferation through DNA and RNA syntheses and ATP energy supply.

This entry presents hypoxanthine phosphoribosyltransferase (EC:, which belongs to phosphoribosyltransferase family and is involved in purine salvage.

GO terms

Biological Process

GO:0006166 purine ribonucleoside salvage

Molecular Function

GO:0004422 hypoxanthine phosphoribosyltransferase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.