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CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF.

X-ray diffraction
2.5Å resolution
PDB entry 1oz0 coloured by chain, front view.
PDB entry 1oz0 coloured by chain, side view.
PDB entry 1oz0 coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bifunctional purine biosynthesis protein ATIC
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Multimeric state: homo dimer
Accessible surface area: 43244.5 Å2
Buried surface area: 15739.17 Å2
Dissociation area: 6,633.25 Å2
Dissociation energy (ΔGdiss): 82.56 kcal/mol
Dissociation entropy (TΔSdiss): 16.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151981

Macromolecules

Bifunctional purine biosynthesis protein ATIC
Chains: A, B
Length: 613 amino acids
Theoretical weight: 66.67 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31335 (Residues: 1-593; Coverage: 100%)
Gene names: ATIC, PURH
Pfam:
InterPro:
CATH:
SCOP:
Bifunctional purine biosynthesis protein ATIC in PDB entry 1oz0, assembly 1, front view.
Bifunctional purine biosynthesis protein ATIC in PDB entry 1oz0, assembly 1, side view.
Bifunctional purine biosynthesis protein ATIC in PDB entry 1oz0, assembly 1, top view.
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