Domain

AICAR transformylase, insert domain (IPR024050)

Short name: AICAR_Tfase_insert_dom

Domain relationships

None.

Description

This domain is found in the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT). AICARFT can be part of a bifunctional enzyme catalysing the last two steps in de novo purine biosynthesis and having also an IMP (Inosine monophosphate) cyclohydrolase EC:3.5.4.10 (IMPCHase) functional domain. The bifunctional enzyme forms an intertwined dimer where each monomer is composed of two separate functional domains.

This entry represents a small alpha domain inserted into the AICARFT formyltransferase domain [PMID: 11323713].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D