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COMPLEX OF TRANSKETOLASE WITH THIAMIN DIPHOSPHATE, CA2+ AND ACCEPTOR SUBSTRATE ERYTHROSE-4-PHOSPHATE

Source organism: Saccharomyces cerevisiae
Biochemical function: metal ion binding
Biological process: purine nucleotide metabolic process
Cellular component: cytosol

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EC 2.2.1.1: Transketolase

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Systematic name:
Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Alternative Name(s):
  • Glycoaldehyde transferase
  • Glycolaldehydetransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02780
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of Pfam domain PF02780 (Transketolase, C-terminal domain) in Transketolase 1. Showing 1 copy in chain A.

PF02779
Domain description: Transketolase, pyrimidine binding domain
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of Pfam domain PF02779 (Transketolase, pyrimidine binding domain) in Transketolase 1. Showing 1 copy in chain A.

PF00456
Domain description: Transketolase, thiamine diphosphate binding domain
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of Pfam domain PF00456 (Transketolase, thiamine diphosphate binding domain) in Transketolase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005474
Domain description: Transketolase, N-terminal
Occurring in:
  1. Transketolase 1
IPR009014
Domain description: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Occurring in:
  1. Transketolase 1
IPR005475
Domain description: Transketolase-like, pyrimidine-binding domain
Occurring in:
  1. Transketolase 1
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. Transketolase 1
IPR033248
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. Transketolase 1
IPR020826
Domain description: Transketolase binding site
Occurring in:
  1. Transketolase 1
IPR005478
Domain description: Transketolase, bacterial-like
Occurring in:
  1. Transketolase 1
IPR033247
Domain description: Transketolase family
Occurring in:
  1. Transketolase 1

Structure domains

CATH CATH domains
3.40.50.970
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 4 copies of CATH domain 3.40.50.970 (Rossmann fold) in Transketolase 1. Showing 2 copies in chain A.
3.40.50.920
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of CATH domain 3.40.50.920 (Rossmann fold) in Transketolase 1. Showing 1 copy in chain A.
SCOP SCOP annotations
52923
Class: Alpha and beta proteins (a/b)
Fold: TK C-terminal domain-like
Superfamily: TK C-terminal domain-like
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of SCOP domain 52923 (Transketolase C-terminal domain-like) in Transketolase 1. Showing 1 copy in chain A.
88735
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of SCOP domain 88735 (TK-like Pyr module) in Transketolase 1. Showing 1 copy in chain A.
88760
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. Transketolase 1
The deposited structure of PDB entry 1ngs contains 2 copies of SCOP domain 88760 (TK-like PP module) in Transketolase 1. Showing 1 copy in chain A.

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