Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Prothrombin/thrombin
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- EGF-like domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- EGF-like calcium-binding domain
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
5 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Thrombin-Thrombomodulin complex (preferred)
PDBe Complex ID:
PDB-CPX-133072 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):