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The structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a 4-helix bundle stalk

X-ray diffraction
3.301Å resolution
PDB entry 3t1e coloured by chain, front view.
PDB entry 3t1e coloured by chain, side view.
PDB entry 3t1e coloured by chain, top view.
Source organism: Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin-neuraminidase
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Multimeric state: homo octamer
Accessible surface area: 71715.99 Å2
Buried surface area: 13336.65 Å2
Dissociation area: 1,669.83 Å2
Dissociation energy (ΔGdiss): -1.23 kcal/mol
Dissociation entropy (TΔSdiss): 27.69 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146264

Macromolecules

Hemagglutinin-neuraminidase
Chains: A, B, E, F
Length: 537 amino acids
Theoretical weight: 58.7 KDa
Source organism: Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12554 (Residues: 49-570; Coverage: 92%)
Gene name: HN
Pfam: Haemagglutinin-neuraminidase
InterPro:
CATH: Neuraminidase
Hemagglutinin-neuraminidase in PDB entry 3t1e, assembly 1, front view.
Hemagglutinin-neuraminidase in PDB entry 3t1e, assembly 1, side view.
Hemagglutinin-neuraminidase in PDB entry 3t1e, assembly 1, top view.
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