PDBe 3t1e

X-ray diffraction
3.3Å resolution

The structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a 4-helix bundle stalk

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin-neuraminidase Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 537 amino acids
Theoretical weight: 58.7 KDa
Source organism: Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12554 (Residues: 49-570; Coverage: 92%)
Gene name: HN
Structure domains: Neuraminidase

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P43212
Unit cell:
a: 138.292Å b: 138.292Å c: 167.338Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.248 0.31
Expression system: Spodoptera frugiperda