Haemagglutinin/haemagglutinin-neuraminidase, paramyxovirus (IPR000665)

Short name: Hemagglutn/HN

Overlapping homologous superfamilies

Family relationships


This entry represents the haemagglutinin-neuraminidase (HN) glycoprotein found in a variety of paramyxoviruses (negative-stranded RNA viruses), including Mumps virus, Human parainfluenza virus 3, and the avian pathogen Newcastle disease virus. It also includes hemagglutinin glycoproteins from Morbiliviruses, a genus belonging to the Paramyxoviridae family that includes the Measles virus. Morbiliviruses hemagglutinins have no neuraminidase activity [PMID: 18026116].

HN is a multi-functional protein with three distinct functions: a receptor-binding (haemagglutinin) activity, a receptor-destroying (neuraminidase) activity, and a membrane fusion activity that fuses the viral envelope to the host cell membrane in order to infect the cell.

GO terms

Biological Process

GO:0019058 viral life cycle

Molecular Function

GO:0046789 host cell surface receptor binding

Cellular Component

GO:0019031 viral envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.