3o44 Summary

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Crystal Structure of the Vibrio cholerae Cytolysin (HlyA) Heptameric Pore

The structure was published by De, S. and Olson, R., in 2011 in a paper entitled "Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.88 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hemolysin.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
B Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
C Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
D Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
E Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
F Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
G Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
H Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
I Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
J Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
K Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
L Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
M Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%
N Hemolysin C2C744 (149-741) (C2C744_VIBCL)search Vibrio cholerae 12129(1)search < 90% 593 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
C2C744 (149 - 741) Hemolysin Vibrio cholerae 12129(1)

Chain Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L, M, N Ricin-type beta-trefoil lectin domainsearch, Leukocidin/Hemolysin toxin familysearch, Hemolytic toxin N terminalsearch

Chain ID Biological process (GO) Cellular component (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N (C2C744) cytolysis in other organismsearch extracellular regionsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N Ricin B lectin domainsearch Leukocidin/porinsearch Hemolytic toxin, N-terminalsearch