Domain

Leukocidin/Hemolysin toxin (IPR016183)

Short name: Leukocidin/Hemolysin_toxin

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents a structural domain consisting of a beta-sandwich fold with an immunoglobulin-like Greek-key topology, and a beta-ribbon arm that forms an oligomeric transmembrane barrel. Haemolysins attack blood cell membranes and cause cell rupture by forming water-filled homoheptameric transmembrane pores. Leukocidin consists of two polypeptides, F and S, and form pores in polymorphonuclear leukocytes [PMID: 16195546].

GO terms

Biological Process

GO:0051715 cytolysis in other organism

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam