› 3gd4

X-ray diffraction
2.24Å resolution

Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor

Released:
DOI: 10.2210/pdb3gd4/pdb
PDB entry 3gd4 coloured by chain, front view.
PDB entry 3gd4 coloured by chain, side view.
PDB entry 3gd4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Redox-linked conformational dynamics in apoptosis-inducing factor.
Sevrioukova IF
J Mol Biol 390 924-38 (2009)
PMID: 19447115

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis-inducing factor 1, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.58 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z0X1 (Residues: 102-612; Coverage: 84%)
Gene names: Aif, Aifm1, Pdcd8
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FAD 2 x FAD
Ligand NAD 2 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 60.26Å b: 120.39Å c: 178.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.222
Expression system: Escherichia coli

Quick links

Citations

10 review citations

AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics.
Delavallée et al. (2011)
9 more

4 mentions without citation

Apoptosis-inducing factor: structure, function, and redox regulation.
Sevrioukova IF. (2011)
3 more