Mitochondrial apoptosis-inducing factor, C-terminal domain (IPR029324)

Short name: AIF_C

Overlapping homologous superfamilies

Domain relationships


This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1 protein. The domain also appears at the C terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis [PMID: 10913597]. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important [PMID: 19447115].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.