Function and Biology Details
Reaction catalysed:
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assemblies composition:
Assembly name:
Insulin-degrading enzyme (preferred)
PDBe Complex ID:
PDB-CPX-152944 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-degrading enzyme
Molecule details ›
Chain: A
Length: 978 amino acids
Theoretical weight: 113.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 978 amino acids
Theoretical weight: 113.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P35559 (Residues: 42-1019; Coverage: 96%)
Sequence domains:
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
- Middle or third domain of peptidase_M16
- PQQ synthase PqqF-like, C-terminal lobe domain 4
