Domain

Peptidase M16, N-terminal (IPR011765)

Short name: Pept_M16_N

Domain relationships

None.

Description

This entry represents an N-terminal domain found in metallopeptidases and non-peptidase homologues belonging to MEROPS peptidase family M16 (clan ME), subfamilies M16A, M16B and M16C. Members of this family include:

  • Insulinase, insulin-degrading enzyme (EC:3.4.24.56)
  • Mitochondrial processing peptidase alpha subunit, (Alpha-MPP, EC:3.4.24.64)
  • Pitrlysin, Protease III precursor (EC:3.4.24.55)
  • Nardilysin, (EC:3.4.24.61)
  • Ubiquinol-cytochrome C reductase complex core protein I,mitochondrial precursor (EC:1.10.2.2)
  • Coenzyme PQQ synthesis protein F (EC:3.4.99)

These proteins do not share many regions of sequence similarity; the most noticeable is in the N-terminal section. This region includes a conserved histidine followed, two residues later by a glutamate and another histidine. In pitrilysin, it has been shown [PMID: 7990931] that this H-x-x-E-H motif is involved in enzymatic activity; the two histidines bind zinc and the glutamate is necessary for catalytic activity. The proteins classified as non-peptidase homologues either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam