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Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein

X-ray diffraction
1.62Å resolution
PDB entry 2x6m coloured by chain, front view.
PDB entry 2x6m coloured by chain, side view.
PDB entry 2x6m coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 6534.52 Å2
Buried surface area: 615.16 Å2
Dissociation area: 307.58 Å2
Dissociation energy (ΔGdiss): -0.61 kcal/mol
Dissociation entropy (TΔSdiss): 6.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211187

Macromolecules

HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY
Chain: A
Length: 126 amino acids
Theoretical weight: 13.44 KDa
Source organism: Camelus dromedarius
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY in PDB entry 2x6m, assembly 1, front view.
HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY in PDB entry 2x6m, assembly 1, side view.
HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY in PDB entry 2x6m, assembly 1, top view.
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Alpha-synuclein
Chain: B
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P37840 (Residues: 132-140; Coverage: 6%)
Gene names: NACP, PARK1, SNCA
Alpha-synuclein in PDB entry 2x6m, assembly 1, front view.
Alpha-synuclein in PDB entry 2x6m, assembly 1, side view.
Alpha-synuclein in PDB entry 2x6m, assembly 1, top view.
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