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EBI PDBe PDBeView

PDBe Entry: 1zmc view

Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NAD+
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.53 Å, R-factor: 21.1%, Free R-factor: 26.7%, Spacegroup: P 21 21 2
Released 28/06/2005, deposition: 10/05/2005, last revision: 24/02/2009
Authors Brautigam, C.A.search; Chuang, J.L.search; Tomchick, D.R.search; Machius, M.search; Chuang, D.T.search
Primary citation Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD(+)/NADH Binding and the Structural Basis of Disease-causing Mutations
J.MOL.BIOL.search vol:350, pag:543-552 (2005) [PubMed ID 15946682 ]search
Keywords E3search, lipoamide dehydrogenasesearch, pyruvate dehydrogenasesearch, alpha-ketoglutarate dehydrogenasesearch, branched-chain alpha-ketoacid dehydrogenasesearch, glycine decarboxylasesearch, glycine cleavagesearch, OXIDOREDUCTASEsearch
EC 1.8.1.4 ExPASy BRENDA search (A B C D E F G H)
Organism Homo sapiens(human) 9606search(A B C D E F G H)
UniProt Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) P09622search (A B C D E F G H)
Solvent A, B, C, D, E, F, G, H
Related entries 1zmd
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D, E, F, G, H Dihydrolipoyl dehydrogenase Protein P09622 (DLDH_HUMAN)search
 474 100%
Heterogens
Id Name Ligands
A, B, C, D, E, F, G, H SULFATE ION SO4 search
A, B, C, D, E, F, G, H FLAVIN-ADENINE DINUCLEOTIDE FAD search
A, B, C, D, E, F, G, H NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD search
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