Dihydrolipoamide dehydrogenase (IPR006258)

Short name: Lipoamide_DH

Overlapping homologous superfamilies

Family relationships


These sequences represent dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N terminus contains a redox-active disulphide.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.