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Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

X-ray diffraction
2.42Å resolution
PDB entry 1m4u coloured by chain, front view.
PDB entry 1m4u coloured by chain, side view.
PDB entry 1m4u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bone morphogenetic protein 7 and Noggin
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Multimeric state: hetero tetramer
Accessible surface area: 34383.88 Å2
Buried surface area: 12286.13 Å2
Dissociation area: 3,327.86 Å2
Dissociation energy (ΔGdiss): 57.02 kcal/mol
Dissociation entropy (TΔSdiss): 14.85 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148283

Macromolecules

Bone morphogenetic protein 7
Chain: L
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Pfam: Transforming growth factor beta like domain
InterPro:
CATH: Cystine-knot cytokines
SCOP: Transforming growth factor (TGF)-beta
Bone morphogenetic protein 7 in PDB entry 1m4u, assembly 1, front view.
Bone morphogenetic protein 7 in PDB entry 1m4u, assembly 1, side view.
Bone morphogenetic protein 7 in PDB entry 1m4u, assembly 1, top view.
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Noggin
Chain: A
Length: 206 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13253 (Residues: 28-232; Coverage: 100%)
Gene name: NOG
Pfam: Noggin
InterPro:
CATH:
SCOP: Noggin
Noggin in PDB entry 1m4u, assembly 1, front view.
Noggin in PDB entry 1m4u, assembly 1, side view.
Noggin in PDB entry 1m4u, assembly 1, top view.
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