Noggin (IPR008717)

Short name: Noggin

Overlapping homologous superfamilies

Family relationships



Noggin was first discovered by its ability to induce secondary axis formation in Xenopus embryos [PMID: 1339313]. It is a secreted homodimeric glycoprotein that serves as a BMP (bone morphogenetic protein) antagonist [PMID: 21256973, PMID: 15951218]. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation [PMID: 12633782]. In humans increased noggin activity results in skeletal dysplasia such as proximal symphalangism (SYM1) and multiple synostosis syndrome 1 (SYNS1) [PMID: 21256973]. Noggin maintains prolonged growth of human embryonic stem cells in vitro and regulates the stem cell niche during neurogenesis [PMID: 15809086, PMID: 11163261].

GO terms

Biological Process

GO:0030514 negative regulation of BMP signaling pathway
GO:0045596 negative regulation of cell differentiation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.