› 1iiy

Solution NMR

Solution NMR Structure of Complex of 1:2 Cyanovirin-N:Man-Alpha1,2-Man-Alpha Restrained Regularized Mean Coordinates

Released:
DOI: 10.2210/pdb1iiy/pdb
PDB entry 1iiy coloured by chain, front view.
PDB entry 1iiy coloured by chain, side view.
PDB entry 1iiy coloured by chain, top view.
Source organism: Nostoc ellipsosporum
Primary publication:
Solution structure of a cyanovirin-N:Man alpha 1-2Man alpha complex: structural basis for high-affinity carbohydrate-mediated binding to gp120.
Bewley CA
Structure 9 931-40 (2001)
PMID: 11591348

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160489 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cyanovirin-N Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.02 KDa
Source organism: Nostoc ellipsosporum
UniProt:
  • Canonical: P81180 (Residues: 1-101; Coverage: 100%)
Sequence domains: CVNH domain
Structure domains: Cyanovirin-N

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CONJOINED RIGID BODY/TORSION ANGLE DYNAMICS

Quick links

Citations

19 review citations

Inhibiting sexual transmission of HIV-1 infection.
Shattock et al. (2003)
18 more

10 mentions without citation

An update of the recombinant protein expression systems of Cyanovirin-N and challenges of preclinical development.
Lotfi et al. (2018)
9 more